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Abstract #0581

Using low dose prostate dynamic contrast enhanced MRI data to verify newly developed eight-parameter mathematical form of arterial input function

Xiaobing Fan1, Shiyang Wang1, Milica Medved 1, Tatjana Antic2, Serkan Guneyli 1, Aytekin Oto 1, and Gregory S Karczmar 1

1Radiology, University of Chicago, Chicago, IL, United States, 2Pathology, University of Chicago, Chicago, IL, United States

Accurate measurements of the arterial input function (AIF) are needed in pharmacokinetic models to analyze dynamic contrast enhanced (DCE) MRI data. The AIF often cannot be accurately measured due to T2* and water exchange effects. Therefore, population AIFs are often employed in pharmacokinetic modeling. Here we report a new 8-parameter empirical mathematical model (EMM) that fits the AIF measured directly from the external femoral artery after a dose of contrast agent that was greatly reduced to minimize artifacts. The results showed that the EMM-AIF accurately models both 1st and 2nd passes of contrast agent circulations.

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