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Abstract #0582

Quantitative DCE and DWI Characterization of the Index Lesion in Multiparametric MRI of Prostate Cancer Patients

Qing Yuan1, Daniel N Costa1,2, Julien Sénégas3, Yin Xi1, Andrea J Wiethoff2,4, Robert E Lenkinski1,2, and Ivan Pedrosa1,2

1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3Philips Research Laboratories, Hamburg, Germany, 4Philips Research North America, Cambridge, MA, United States

We investigated the use of quantitative DWI and DCE measurements in MRI-visible index lesions as a surrogate for aggressiveness in prostate cancer patients. Tissue diffusion coefficient from simplified intravoxel incoherent motion model from DWI, and initial area under the curve from DCE offered the best performance in discriminating low and intermediate-to-high risk tumors. Anatomic and functional multiparametric MRI may provide a more reliable assessment of the aggressiveness of prostate cancer in patients.

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