Abstract #0582

Quantitative DCE and DWI Characterization of the Index Lesion in Multiparametric MRI of Prostate Cancer Patients

Qing Yuan¹, Daniel N Costa^1,2, Julien Sénégas³, Yin Xi¹, Andrea J Wiethoff^2,4, Robert E Lenkinski^1,2, and Ivan Pedrosa^1,2

¹Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ²Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, ³Philips Research Laboratories, Hamburg, Germany, ⁴Philips Research North America, Cambridge, MA, United States

We investigated the use of quantitative DWI and DCE measurements in MRI-visible index lesions as a surrogate for aggressiveness in prostate cancer patients. Tissue diffusion coefficient from simplified intravoxel incoherent motion model from DWI, and initial area under the curve from DCE offered the best performance in discriminating low and intermediate-to-high risk tumors. Anatomic and functional multiparametric MRI may provide a more reliable assessment of the aggressiveness of prostate cancer in patients.

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