Abstract #0588

Detecting diffuse cardiac fibrosis with T1ρ MRI

Joep van Oorschot¹, Fatih Guclu², Peter Luijten¹, Tim Leiner¹, and Jaco Zwanenburg¹

¹Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ²Cardiology, University Medical Center Utrecht, Utrecht, Netherlands

Native T1ρ-mapping is a promising non-contrast enhanced method for fibrosis detection, that would overcome problems associated with contrast agent use. In this work, we will evaluate the performance of T1ρ-mapping versus ECV-m and native T1 in DCM patients. Native T1, native T1ρ and Contrast enhanced T1-maps were acquired in twelve DCM patients, and 8 healthy volunteers. The T1ρ relaxation time was significantly higher in the DCM patients (55.6 ± 3.0 ms), compared to the healthy control subjects (51.5 ± 1.2 ms), p<0.005. A significant correlation was found between the T1ρ relaxation time and the Extracellular Volume fraction in patients.

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