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Abstract #0588

Detecting diffuse cardiac fibrosis with T1ρ MRI

Joep van Oorschot1, Fatih Guclu2, Peter Luijten1, Tim Leiner1, and Jaco Zwanenburg1

1Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Cardiology, University Medical Center Utrecht, Utrecht, Netherlands

Native T1ρ-mapping is a promising non-contrast enhanced method for fibrosis detection, that would overcome problems associated with contrast agent use. In this work, we will evaluate the performance of T1ρ-mapping versus ECV-m and native T1 in DCM patients. Native T1, native T1ρ and Contrast enhanced T1-maps were acquired in twelve DCM patients, and 8 healthy volunteers. The T1ρ relaxation time was significantly higher in the DCM patients (55.6 ± 3.0 ms), compared to the healthy control subjects (51.5 ± 1.2 ms), p<0.005. A significant correlation was found between the T1ρ relaxation time and the Extracellular Volume fraction in patients.

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