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Abstract #0592

MRI Assessment of Coronary Endothelial Function using Native T1 Mapping with Nitric Oxide Synthase (NOS) Inhibition

Sophia Xinyuan Cui1 and Frederick H. Epstein1,2

1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 2Radiology, University of Virginia, Charlottesville, VA, United States

Endothelial nitric oxide synthase (eNOS)-mediated production of NO is an important system regulating the microvasculature, controlling both vessel diameter and permeability. We hypothesized that T1 mapping of the heart during NOS inhibition could detect increased water content resulting from increased microvascular permeability, providing a novel means to noninvasively probe eNOS regulation of the coronary microvasculature. T1-mapping in mice after intravenous NOS inhibition detected an increase in myocardial T1 of 113±15 ms compared to baseline (p<0.05). These methods are likely probing eNOS regulation of coronary microvascular permeability, which may represent a novel means of assessing the health of the coronary endothelium.

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