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Abstract #0593

Accuracy of cardiac magnetic resonance T1 mapping for detecting diffuse myocardial fibrosis: comprehensive comparison with the pathology in diabetic rabbits

Mu Zeng1, Nan Zhang1, Yi He1, Jing An2, Andreas Greiser3, and Zhanming Fan1

1Radiology, Beijing Anzhen Hospital,Capital medical university, Beijing, China, People's Republic of, 2MR Collaborations NE Asia, Siemens Healthcare, Beijing, China, Beijing, China, People's Republic of, 3Siemens AG Healthcare Sector MR, Erlangen, Germany

In recent years, use of the MRI T1 mapping technique to detect diffuse myocardial fibrosis has received increasing attention. Although previous studies have verified the relationship between T1 mapping and pathological findings, our study is the first to show continuity during the observation of a single disease while avoiding interference caused by other diseases. In addition, the pathology can be fully verified in real time using animal experiments.

The main findings of this study were that (1) the ECV obtained from the MRI T1 mapping sequence was highly correlated with the CVF in terms of the degree of histologically diffuse interstitial fibrosis; (2) the correlation between the native T1 value and the CVF change was not strong; and (3) the rabbit is a suitable model for cardiac magnetic resonance research using clinical equipment.

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