In recent years, use of the MRI T1 mapping technique to detect diffuse myocardial fibrosis has received increasing attention. Although previous studies have verified the relationship between T1 mapping and pathological findings, our study is the first to show continuity during the observation of a single disease while avoiding interference caused by other diseases. In addition, the pathology can be fully verified in real time using animal experiments.
The main findings of this study were that (1) the ECV obtained from the MRI T1 mapping sequence was highly correlated with the CVF in terms of the degree of histologically diffuse interstitial fibrosis; (2) the correlation between the native T1 value and the CVF change was not strong; and (3) the rabbit is a suitable model for cardiac magnetic resonance research using clinical equipment.
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