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Abstract #0601

Relationship between Cerebrovascular Reserve and Brain Temperature following Acetazolamide Challenge in Patients with Chronic Steno-Occlusive Disease

Seena Dehkharghani1, Candace C. Fleischer2, Deqiang Qiu1, Sang-Eon Park2, Junjie Wu1, and Fadi Nahab3

1Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States, 2Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, United States, 3Neurology, Emory University, Atlanta, GA, United States

Methods for characterizing misery perfusion to predict stroke are largely limited to positron emission tomography, which suffers from high radiation exposure. Magnetic resonance imaging (MRI) and spectroscopy (MRS) offer non-invasive alternatives to explore cerebral hemodynamics and brain temperature regulation, a poorly understood physiologic variable at the intersection of perfusion and metabolism. We detail the first reported use of MRI/MRS to relate cerebrovascular reserve with temperature in patients following acetazolamide challenge, observing significant correlation between temperature changes and cerebrovascular reserve. These findings will be used to inform future MRI studies of perfusion and brain temperature among patients with chronic steno-occlusive disease.

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