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Abstract #0607

Generalized SLIce Dithered Enhanced Resolution Simultaneous MultiSlice (gSlider-SMS) to increase volume encoding, SNR and partition profile fidelity in high-resolution diffusion imaging.

Kawin Setsompop1, Jason Stockmann1, Qiuyun Fan1, Thomas Witzel1, and Lawrence L. Wald1

1A.A. Martinos Center for Biomedical Imaging, charlestown, MA, United States

In this work, we propose generalized Slider (gSlider) method which utilizes RF encoding to markedly improve the ability of slice super-resolution in acquiring a large number of imaging slices simultaneously in diffusion imaging, to increase volume encoding and SNR. In particular, we show that gSlider can be use to acquire 5 slices simultaneously to provide close to the theoretical √5 SNR gain, while retaining sharp slice/partition resolution, comparable to that of conventional 2-D slice-selective imaging. Through a combined gSlider-SMS acquisition (5x-gSlider and MB-2), we demonstrate a highly efficient 10 simultaneous slice acquisition for high quality whole-brain 660μm isotropic diffusion imaging.

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