Abstract #0607

Generalized SLIce Dithered Enhanced Resolution Simultaneous MultiSlice (gSlider-SMS) to increase volume encoding, SNR and partition profile fidelity in high-resolution diffusion imaging.

Kawin Setsompop¹, Jason Stockmann¹, Qiuyun Fan¹, Thomas Witzel¹, and Lawrence L. Wald¹

¹A.A. Martinos Center for Biomedical Imaging, charlestown, MA, United States

In this work, we propose generalized Slider (gSlider) method which utilizes RF encoding to markedly improve the ability of slice super-resolution in acquiring a large number of imaging slices simultaneously in diffusion imaging, to increase volume encoding and SNR. In particular, we show that gSlider can be use to acquire 5 slices simultaneously to provide close to the theoretical √5 SNR gain, while retaining sharp slice/partition resolution, comparable to that of conventional 2-D slice-selective imaging. Through a combined gSlider-SMS acquisition (5x-gSlider and MB-2), we demonstrate a highly efficient 10 simultaneous slice acquisition for high quality whole-brain 660μm isotropic diffusion imaging.

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