Abstract #0629

Changed Brain Connectivity in Elderly APOE ε4 Carriers: a Whole-brain Voxel-wise Functional Connectivity Strength Analysis

Kai Liu¹, Teng Zhang¹, Yanjia Deng¹, Lin Shi^2,3, Defeng Wang^4,5, and ADNI Alzheimer’s Disease Neuroimaging Initiative ⁶

¹Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ³Chow Yuk Ho Technology Centre for Innovative Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁴Research Center for Medical Image Computing, Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁵Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China, People's Republic of, ⁶Los Angeles, SC, United States

Apolipoprotein E epsilon 4 allele (APOE-4) is considered as the strongest genetic risk factor for late-onset Alzheimer’s disease, and investigation of its neuropathological effect in normal elderly using advanced neuroimaging connectivity probes has brought much research curiosity. In this study, the underlying abnormal brain connectivity in APOE-4 carriers was analyzed using the functional connectivity strength (FCS), which provides a voxel-wise method to explore the significant connectivity changes at whole-brain level. The results identified APOE-4 related significant connectivity decrease in the bilateral insular and left temporal lobe. We hope these findings could help to shed light on the APOE-4’s neuropathological mechanism.

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