Abstract #0630

Who will develop Alzheimer’s disease? New insights from multimodal neuroimaging

Letizia Casiraghi^1,2, Fulvia Palesi^2,3, Gloria Castellazzi^2,4, Andrea De Rinaldis^2,4, Elena Sinforiani⁵, Claudia Angela Michela Gandini Wheeler-Kingshott ^2,6, Egidio D'Angelo^1,2, and Carol Di Perri²

¹Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, ²Brain Connectivity Center, C. Mondino National Neurological Institute, Pavia, Italy, ³Department of Physics, University of Pavia, Pavia, Italy, ⁴Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy, ⁵Neurology Unit, C. Mondino National Neurological Institute, Pavia, Italy, ⁶NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, University College London, London, United Kingdom

Mild cognitive impairment (MCI) is considered a transitional state between healthy controls (HC) and Alzheimer’s disease (AD). This study compares the predictive value of neuropsychological evaluation, structural magnetic resonance imaging, diffusion tensor imaging and resting state functional MRI indices able to identify MCI conversion. AD versus HC and converted MCI (cMCI) versus non-converted MCI (ncMCI) presented different features of differentiation. This result suggests adopting advanced MRI techniques to investigate early alterations. Due to the clinical heterogeneity of MCI patients, considering cMCI as AD-like and ncMCI as HC might be inappropriate when attempting to distinguishing between cMCI and non-converted MCI.

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