Abstract #0638

Effects of Anesthesia on White Matter BOLD Signals in Monkeys

Tung-Lin Wu^1,2, Feng Wang^1,3, Li Min Chen^1,3, Adam W. Anderson^1,2,3, Zhaohua Ding^1,3, and John C. Gore^1,2,3

¹Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, ²Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ³Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States

We previously reported the first evidence of anisotropic rsfMRI-BOLD signals in white matter which appear to reflect a functional structure not previously detected. To prove these signals have a functional basis, we performed imaging of live squirrel monkeys under different baselines of neural activity by altering anesthesia levels. Specifically, we compared how different anesthesia levels modulate fractional power and spatio-temporal correlation tensors in white matter. Our results demonstrate that low frequency BOLD signal fluctuations behave similarly in grey and white matter. This indicates that anisotropic rsfMRI-BOLD signals in white matter encode neural activity.

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