Li-Ming Hsu1, Gu Hong1, Hanbing Lu1, Elisabeth C. Caparelli1, Elliot A. Stein1, and Yihong Yang1
Intrinsic brain networks seen in humans,
including the default-mode network (DMN), have been demonstrated in non-human
primates and rodents using resting-state functional fMRI (rs-fMRI). Characteristics
of these brain networks, such as frequency specificity, have been assessed in
humans, but are much less known in animal models. These characteristics are
of importance when translating findings from preclinical models to clinical
applications. The frequency range used in a human rs-fMRI analysis is typically
≤ 0.1 Hz; however, an
appropriate frequency range in rodents remains unclear. In this study, we
investigated the resting-state functional connectivity (rsFC) of rat brains in
three frequency ranges: 1) 0.01 – 0.1 Hz, 2) 0.1 – 0.25 Hz, and 3) 0.25 – 0.5
Hz, and compared the result with that in human brains.
