Meeting Banner
Abstract #0640

Frequency specificity of functional connectivity in rat brain networks

Li-Ming Hsu1, Gu Hong1, Hanbing Lu1, Elisabeth C. Caparelli1, Elliot A. Stein1, and Yihong Yang1

1Neuroimaging Research Branch, National institute on drug abuse, Baltimore, MD, United States

Intrinsic brain networks seen in humans, including the default-mode network (DMN), have been demonstrated in non-human primates and rodents using resting-state functional fMRI (rs-fMRI). Characteristics of these brain networks, such as frequency specificity, have been assessed in humans, but are much less known in animal models. These characteristics are of importance when translating findings from preclinical models to clinical applications. The frequency range used in a human rs-fMRI analysis is typically ≤ 0.1 Hz; however, an appropriate frequency range in rodents remains unclear. In this study, we investigated the resting-state functional connectivity (rsFC) of rat brains in three frequency ranges: 1) 0.01 – 0.1 Hz, 2) 0.1 – 0.25 Hz, and 3) 0.25 – 0.5 Hz, and compared the result with that in human brains.

This abstract and the presentation materials are available to members only; a login is required.

Join Here