Abstract #0640

Frequency specificity of functional connectivity in rat brain networks

Li-Ming Hsu¹, Gu Hong¹, Hanbing Lu¹, Elisabeth C. Caparelli¹, Elliot A. Stein¹, and Yihong Yang¹

¹Neuroimaging Research Branch, National institute on drug abuse, Baltimore, MD, United States

Intrinsic brain networks seen in humans, including the default-mode network (DMN), have been demonstrated in non-human primates and rodents using resting-state functional fMRI (rs-fMRI). Characteristics of these brain networks, such as frequency specificity, have been assessed in humans, but are much less known in animal models. These characteristics are of importance when translating findings from preclinical models to clinical applications. The frequency range used in a human rs-fMRI analysis is typically ≤ 0.1 Hz; however, an appropriate frequency range in rodents remains unclear. In this study, we investigated the resting-state functional connectivity (rsFC) of rat brains in three frequency ranges: 1) 0.01 – 0.1 Hz, 2) 0.1 – 0.25 Hz, and 3) 0.25 – 0.5 Hz, and compared the result with that in human brains.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.