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Abstract #0641

The resting state fMRI global signal is negatively correlated with time-varying EEG vigilance

Maryam Falahpour1, Chi Wah Wong1, and Thomas T. Liu1

1Center for Functional Magnetic Resonance Imaging, University of California San Diego, San Diego, CA, United States

Global signal (GS) regression is a commonly used preprocessing approach in the analysis of resting-state fMRI data. However GSR should be used with caution as it can not only induce spurious anti-correlations, but may also remove signal of neural origin. Here we used simultaneously acquired EEG/fMRI data to study the relation between the GS and an EEG-based measure of vigilance at rest. We found that there is a significant negative correlation between the GS and EEG vigilance. Our results indicate that GS has a significant neuronal component and further emphasizes the need to exercise caution when regressing out the GS.

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