Abstract #0641

The resting state fMRI global signal is negatively correlated with time-varying EEG vigilance

Maryam Falahpour¹, Chi Wah Wong¹, and Thomas T. Liu¹

¹Center for Functional Magnetic Resonance Imaging, University of California San Diego, San Diego, CA, United States

Global signal (GS) regression is a commonly used preprocessing approach in the analysis of resting-state fMRI data. However GSR should be used with caution as it can not only induce spurious anti-correlations, but may also remove signal of neural origin. Here we used simultaneously acquired EEG/fMRI data to study the relation between the GS and an EEG-based measure of vigilance at rest. We found that there is a significant negative correlation between the GS and EEG vigilance. Our results indicate that GS has a significant neuronal component and further emphasizes the need to exercise caution when regressing out the GS.

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