Abstract #0649

Unveiling the Dispersion Kernel in DSC-MRI by Means of Dispersion-Compliant Bases and Control Point Interpolation Techniques

Marco Pizzolato¹, Rutger Fick¹, Timothé Boutelier², and Rachid Deriche¹

¹Athena Project-Team, Inria Sophia Antipolis - Méditerranée, Sophia Antipolis, France, ²Olea Medical, La Ciotat, France

In DSC-MRI the presence of dispersion affects the estimation, via deconvolution, of the residue function that characterizes the perfusion in each voxel. Dispersion is described by a Vascular Transport Function (VTF) which knowledge is essential to recover a dispersion-free residue function. State-of-the-art techniques aim at characterizing the VTF but assume a specific shape for it, which in reality is unknown. We propose to estimate the residue function without assumptions by means of Dispersion-Compliant Bases (DCB). We use these results to find which VTF model better describes the in-vivo data for each tissue type by means of control point interpolation approaches.

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