Abstract #0650

Arterial transit time (ATT) heterogeneity in calf muscle: how DCE studies reveal a critical challenge for arterial spin labeling (ASL) acquisition

Jeff L. Zhang¹, Christopher Hanrahan¹, Christopher C. Conlin¹, Corey Hart², Gwenael Layec², Kristi Carlston¹, Daniel Kim¹, Michelle Mueller³, and Vivian S. Lee¹

¹Radiology, University of Utah, Salt Lake City, UT, United States, ²Internal Medicine, University of Utah, Salt Lake City, UT, United States, ³Vascular surgery, University of Utah, Salt Lake City, UT, United States

One major challenge for measuring exercise perfusion of skeletal muscle with ASL is the potential heterogeneity of arterial transit time (ATT) across the muscle. In this study, we used reliable DCE MRI technique to measure ATT of calf muscle in both healthy controls and peripheral artery disease patients and after plantar flexion of different loads. Our study showed that ATT of calf muscle varied with multiple factors, including muscle group, exercise load and healthy status, and had a wide range of 0~4 sec. The result suggests the necessity of performing calf-muscle ASL with multiple different post-labeling delays.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.