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Abstract #0657

Impact of transcytolemmal water exchange on quantitative characterization of tissue microstructure using diffusion MRI

Hua Li1, Xiaoyu Jiang1, Jingping Xie1, John C Gore1, and Junzhong Xu1

1Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States

Current diffusion MRI methods that quantitatively characterize tissue microstructure usually assume a zero transcytolemmal water exchange rate $$$\tau_{in}$$$ between intra- and extracellular spaces. This assumption may not be true in many cases of interest. The present work used both computer simulations and cell culture in vitro to investigate the influence of $$$\tau_{in}$$$ on the accuracy of fitted microstructural parameters such as mean cell size $$$d$$$, intracellular water fraction $$$f_{in}$$$ and diffusion coefficient $$$D_{in}$$$. Results indicate $$$d$$$ is relatively insensitive to $$$\tau_{in}$$$, while $$$f_{in}$$$ is always underestimated with finite $$$\tau_{in}$$$. $$$D_{in}$$$ can be fit reliably only when short diffusion times are used.

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