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Abstract #0681

Quantitative and Functional Assessment of Red and Yellow Bone Marrow Using PET-MR Imaging

Chuan Huang1,2, Anuradha Janardhanan1,3, and Mark Schweitzer1

1Radiology, Stony Brook Medicine, Stony Brook, NY, United States, 2Psychiatry, Stony Brook Medicine, Stony Brook, NY, United States, 3Diagnostic Imaging, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia

Understanding the distribution of red marrow is important for various hematopoetic diseases and especially osseous metastases as areas of red marrow are the primary sites for hematogenous seeding of tumor cells, accounting for approximately 90% of skeletal metastases. Using a simultaneous PET-MR we sought to evaluate voxel of red marrow in the femora and pelvis using fat/water sequences correlated with FDG PET uptake. This quantitative assessment of red and yellow marrow was done in specific anatomic subregions. The bone marrow composition and metabolism were found to be symmetric in each individual. Good correlation between SUV and %red were found for each ROI among all subjects. The metabolism (FDG uptake) was found to be different for the ROIs with the same amount of red marrow. Further research will study whether this leads to higher chance of tumor seeding.

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