Abstract #0680

Fast volumetric mapping of bound and pore water content in cortical bone in vivo using 3D Cones sequences

Jun Chen¹, Michael Carl², Hongda Shao¹, Eric Chang¹, Graeme Bydder¹, and Jiang Du¹

¹Radiology, University of California, San Diego, San Diego, CA, United States, ²GE Healthcare, San Diego, CA, United States

Bone water exists in the form of free water in the Haversian canals or lacunar-canalicular system, as well as bound water either loosely bound to collagen or more tightly bound to mineral. Ultrashort echo time (UTE) sequences with TEs as short as 8 µs can potentially detect signal from pore water and loosely bound water. In this study, we introduce an approach for fast volumetric mapping of bound and pore water content in vivo using a clinical 3T MR scanner.

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