Abstract #0683

A Method to Quantitatively Compare Bone and Cartilage Changes Post Knee Injury: Initial Results

Uchechukwuka Monu¹, Feliks Kogan², Emily McWalter², Brian Hargreaves², and Garry Gold²

¹Electrical Engineering, Stanford University, Stanford, CA, United States, ²Radiology, Stanford University, Stanford, CA, United States

New PET/MR systems have made the simultaneous acquisition and quantitative assessment of bone and cartilage possible. Using projection maps and cluster analysis, the comprehensive visualization and quantification of PET ¹⁸F-NaF uptake within an injured and contralateral knee are determined and compared with corresponding T2 and T1rho relaxation times within the cartilage. Significant increase in PET uptake is observed in the injured knee compared to the contralateral knee and some areas of high PET uptake correspond with elevated T2 and T1rho relaxation times. This developed tool shows promise in assessing bone metabolic activity and its relationship with quantitative MR parameters.

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