A Method to Quantitatively Compare Bone and Cartilage Changes Post Knee Injury: Initial Results
Uchechukwuka Monu1, Feliks Kogan2, Emily McWalter2, Brian Hargreaves2, and Garry Gold2
1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States
New PET/MR systems have made the
simultaneous acquisition and quantitative assessment of bone and cartilage
possible. Using projection maps and cluster analysis, the comprehensive
visualization and quantification of PET 18F-NaF uptake within an
injured and contralateral knee are determined and compared with corresponding
T2 and T1rho relaxation times within the cartilage. Significant increase in PET
uptake is observed in the injured knee compared to the contralateral knee and
some areas of high PET uptake correspond with elevated T2 and T1rho relaxation
times. This developed tool shows promise in assessing bone metabolic activity
and its relationship with quantitative MR parameters.
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