Abstract #0684

Validation of MRI-based Assessment of Mechanical Competence of Distal Tibia using Cadaveric Human Bone.

Chamith S. Rajapakse¹, Benjamin T. Newman¹, Wenli Sun¹, Michael Ispiryan¹, Michelle Slinger², Elizabeth A. Kobe², Kelly Borges¹, Karyll Davis², Keren De Jesus², Jeremy Magland¹, and Felix W. Wehrli¹

¹Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²University of Pennsylvania School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United States

High-resolution MRI-derived finite element analysis allows for the in vivo estimation of bone strength. This information is useful for planning treatments and interventions in individuals suffering from conditions that affect bone mineral homeostasis. However these methods have not been previously validated. This study subjected distal tibia specimens to both MRI-based finite element analysis and mechanical testing ex vivo. Estimated bone stiffness was strongly correlated to the experimental values (R2=0.84) supporting usefulness of MRI-based bone strength assessment in human subjects.

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