Abstract #0689

Regional iron accumulation is associated with motor impairments in Parkinson’s disease as measured by quantitative susceptibility mapping

Xiaojun Guan¹, Min Xuan¹, Quanquan Gu¹, Xiaojun Xu¹, Chunlei Liu^2,3, Peiyu Huang¹, Nian Wang², Yong Zhang⁴, Wei Luo⁵, and Minming Zhang¹

¹Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, People's Republic of, ²Brain Imaging and Analysis Center, Duke University School of Medicine, Durham, NC, American Samoa, ³Department of Radiology, Duke University School of Medicine, Durham, American Samoa, ⁴MR Research, GE Healthcare, Shanghai, China, People's Republic of, ⁵Neurology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, People's Republic of

We explored the relationships between cerebral iron and the motor impairments in PD. Quantitative susceptibility mapping was used to quantify the iron content in vivo.

Iron content in dentate and red nuclei had close associations with tremor symptom.

Caudate and nigral iron content significantly correlated with akinetic/rigid symptom.

These might support the idea that regional iron is related to the motor impairments.

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