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Abstract #0690

Nigral Iron Distribution in Brain of Parkinson’s Disease: A Combined Structural Voxel-wise and ROI-based Study with Quantitative Susceptibility Mapping

Darrell Ting Hung Li1, Edward Sai Kam Hui1, Queenie Chan2, Nailin Yao3, Siew-eng Chua4, Grainne M. McAlonan4,5, Shu Leong Ho6, and Henry Ka Fung Mak1

1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 2Philips Healthcare, Hong Kong, Hong Kong, 3Department of Psychiatry, Yale University, New Haven, CT, United States, 4Department of Psychiatry, The University of Hong Kong, Hong Kong, Hong Kong, 5Department of Forensic and Neurodevelopmental Science, King’s College London, London, United Kingdom, 6Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong

Abnormal nigral iron deposition is considered one of the major biomarkers in Parkinson’s disease (PD). Extensive studies had been performed to evaluate iron concentration in substantia nigra using different in vivo imaging methods. Whole structure ROI-based analysis of basal nuclei is a majority approach in similar studies. In this study, we investigated the distribution of iron in substantia nigra with both voxel-wise and split ROI methods. Location of significant higher iron concentration was identified to be around pars compacta of the substantia nigra in PD brain. The two methods adopted in this study agreed with each other.

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