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Abstract #0695

Accurate T1 and T2 mapping by direct least-squares ellipse fitting to phase-cycled bSSFP data

Yulia Shcherbakova1, Cornelis A.T. van den Berg2, Jan J.W. Lagendijk3, Chrit T.W. Moonen4, and Lambertus W. Bartels5

1Center for Imaging Sciences/Imaging Division, UMC Utrecht, Utrecht, Netherlands, 2Dept. of Radiotherapy/Imaging Division, UMC Utrecht, Utrecht, Netherlands, 3Department of Radiotherapy/Centre for Image Sciences, UMC Utrecht, Utrecht, Netherlands, 4Center for Imaging Sciences/ Imaging Division, UMC Utrecht, Utrecht, Netherlands, 5Image Sciences Institute/Department of Radiology, UMC Utrecht, Utrecht, Netherlands

Björk et al. proposed to use the balanced steady-state free precession (bSSFP) pulse sequence with multiple phase-cycled acquisitions to estimate the values of T1 and T2 using a non-linear fitting approach. Unfortunately, they found that this non-linear approach would face large uncertainties for realistic SNRs. The purpose of our work was to demonstrate that by reformulating the signal model in the complex plane, an elliptical model can be fitted to the data points using a linear least squares method , allowing for more robust, accurate and simultaneous estimation of T1 and T2 values.

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