Abstract #0696

Influence of pulse length and shape on variable flip angle T1 mapping of the human brain

Yosef Al-Abasse¹ and Gunther Helms¹

¹Medical Radiation Physics, Lund University, Lund, Sweden

Effects of the macromolecular pool are usually neglected in T₁ mapping using the variable flip angle (VFA) method. To demonstrate the influence of magnetization transfer (MT) on the estimated T₁, VFA experiments were performed using sinc and rect pulses of different pulse lengths (0.5 ms ≤ TRF ≤ 2.0 ms). Substantial variations in T₁ (11-21 %) were observed. Longer rect pulses yielded lower T₁ values than those obtained by inversion recovery. This can be explained by varying saturation of macromolecules and inherent MT. A simplified model for the influence of T_RF on the T₁ estimates is suggested for low-power rect pulses.

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