Abstract #0698

Real-time multi-slice MRI during CPAP reveals dynamic changes in upper airway in response to pressure change

Weiyi Chen¹, Ziyue Wu², Sally L. Davidson Ward³, Michael C.K. Khoo⁴, and Krishna S. Nayak¹

¹Electrical Engineering, University of Southern California, Los Angeles, CA, United States, ²Alltech Medical Systems USA, Solon, OH, United States, ³Children's Hospital Los Angeles, Los Angeles, CA, United States, ⁴Biomedical Engineering, University of Southern California, Los Angeles, CA, United States

We demonstrate a novel experiment that captures the upper airway’s instantaneous response to changes in air pressure. We apply rapid changes in continuous positive airway pressure (CPAP) during real-time simultaneous multi-slice MRI. This reveals the airway area does NOT only depend on pressure level but also different airway sections and previous muscle tone status. This technique also enables characterization of airway collapsibility, and is relevant to the assessment of obstructive sleep apnea (OSA) and treatment planning.

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