Abstract #0699

Imaging myelin with ultrashort-echo time (UTE) in a Multiple Sclerosis model on a clinical 7T system

Caroline Guglielmetti¹, Tanguy Boucneau², Peng Cao², Annemie Van der Linden³, Peder Larson², and Myriam M Chaumeil¹

¹University of California San Francisco, San Francisco, CA, United States, ²Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ³University of Antwerp, Antwerp, Belgium

Many advances in neuroimaging have improved diagnosis and care of Multiple Sclerosis (MS) patients. However, current clinical methods fail to detect the majority of cortical lesions. In this work, we used the well characterized cuprizone mouse model for brain demyelination to evaluate the sensitivity of in vivo ultra-short echo time (UTE) measurements for the non-invasive detection of grey and white matter alterations. We showed that UTE enabled the detection of cortical lesions and the assessment of myelin integrity in the white matter following demyelination and spontaneous remyelination.

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