Imaging myelin with ultrashort-echo time (UTE) in a Multiple Sclerosis model on a clinical 7T system
Caroline Guglielmetti1, Tanguy Boucneau2, Peng Cao2, Annemie Van der Linden3, Peder Larson2, and Myriam M Chaumeil1
1University of California San Francisco, San Francisco, CA, United States, 2Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 3University of Antwerp, Antwerp, Belgium
Many advances in
neuroimaging have improved diagnosis and care of Multiple Sclerosis (MS) patients.
However, current clinical methods fail to detect the majority of cortical lesions.
In this work, we used the well characterized cuprizone mouse model for brain
demyelination to evaluate the
sensitivity of in vivo ultra-short
echo time (UTE) measurements for the non-invasive detection of grey and white
matter alterations. We showed that UTE enabled the detection of cortical lesions
and the assessment of myelin integrity in the white matter following demyelination
and spontaneous remyelination.
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