Abstract #0718

Towards Quantitative Renal MR Blood Oximetry by Combined Monitoring of T2*, T2 and Blood Volume Fraction

Andreas Pohlmann¹, Karen Arakelyan^1,2, Leili Riazy¹, Till Huelnhagen¹, Stefanie Kox¹, Kathleen Cantow², Sonia Waiczies¹, Bert Flemming², Erdmann Seeliger², and Thoralf Niendorf¹

¹Berlin Ultrahigh Field Facility, Max Delbrueck Center for Molecular Medicine, Berlin, Germany, ²Institute of Physiology, Charite Universitaetsmedizin, Berlin, Germany

Acute kidney injuries are often characterized by tissue oxygen hypoxia. T₂*-mapping permits probing renal oxygenation but provides a surrogate rather than a quantitative measure of oxygen saturation. The link between pO₂ and T₂* is influenced by changes in blood volume fraction (BVf). Monitoring BVf in combination with recently developed quantitative BOLD approaches could permit unambiguous interpretation of renal T₂*. To test the feasibility of this new approach we monitored renal T₂*/T₂ during baseline and short periods of venous occlusion. This was performed in the same animal under naïve conditions and again with USPIO to permit estimation of BVf and SO₂.

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