Abstract #0719

BOLD MRI of human placenta and fetuses under maternal hyperoxygenation in growth restricted twin pregnancies

Jie Luo^1,2, Esra Abaci Turk^1,2, Carolina Bibbo³, Borjan Gagoski¹, Mark Vangel⁴, Clare M Tempany-Afdhal⁵, Norberto Malpica⁶, Arvind Palanisamy⁷, Elfar Adalsteinsson^2,8,9, Julian N Robinson³, and Patricia Ellen Grant¹

¹Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, ²Madrid-MIT M+Vision Consortium in RLE, Massachusetts Institute of Technology, Cambridge, MA, United States, ³Maternal and Fetal Medicine, Brigham and Women's Hospital, Boston, MA, United States, ⁴Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁵Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States, ⁶Medical Image Analysis and Biometry Laboratory, Universidad Rey Juan Carlos, Madrid, Spain, ⁷Division of Obstetric Anesthesia, Brigham and Women's Hospital, Boston, MA, United States, ⁸Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁹Harvard- MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Adequate oxygen transport across the placenta from mother to fetus is critical for fetal growth and development. In this pilot study, BOLD MRI with maternal hyperoxygenation show great potential in differentiating IUGR fetuses from controls. Not only the placentae show significant difference in rate of oxygen uptake, fetal organs also have distinct response to exposure to hyperoxia. Differences between fetal brain and liver responses to hyperoxygenation are observed in some cases, which might suggest variations in fetal hemodynamic autoregulation.

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