Abstract #0720

Ingestion of carbohydrate solutions of glucose-fructose versus glucose-alone during a prolonged exercise in individuals with type 1 diabetes

Tania Buehler¹, Lia Bally², Ayse Sila Dokumaci¹, Christoph Stettler², and Chris Boesch¹

¹Depts. Radiology and Clinical Research, University of Bern, Bern, Switzerland, ²Division of Endocrinology, Diabetes and Clinical Nutrition, Inselspital Bern, Bern, Switzerland

In comparison to healthy subjects, there is scarce data on the influence of different carbohydrate-types on the metabolism in exercising individuals with type 1 diabetes mellitus (T1DM). Based on ¹³C-MRS, blood sampling, stable isotopes, and indirect calorimetry the impact of glucose-fructose and glucose-alone was investigated in T1DM subjects without prior insulin reduction. Glucose-fructose ingestion showed a shift in fuel metabolism towards increased fat oxidation and potential glycogen sparing effects. Despite the negative reputation of fructose it seems to be a more efficient fuel in exercising T1DM subjects, since blood glucose levels are not immediately elevated due to its different metabolization.

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