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Abstract #0720

Ingestion of carbohydrate solutions of glucose-fructose versus glucose-alone during a prolonged exercise in individuals with type 1 diabetes

Tania Buehler1, Lia Bally2, Ayse Sila Dokumaci1, Christoph Stettler2, and Chris Boesch1

1Depts. Radiology and Clinical Research, University of Bern, Bern, Switzerland, 2Division of Endocrinology, Diabetes and Clinical Nutrition, Inselspital Bern, Bern, Switzerland

In comparison to healthy subjects, there is scarce data on the influence of different carbohydrate-types on the metabolism in exercising individuals with type 1 diabetes mellitus (T1DM). Based on 13C-MRS, blood sampling, stable isotopes, and indirect calorimetry the impact of glucose-fructose and glucose-alone was investigated in T1DM subjects without prior insulin reduction. Glucose-fructose ingestion showed a shift in fuel metabolism towards increased fat oxidation and potential glycogen sparing effects. Despite the negative reputation of fructose it seems to be a more efficient fuel in exercising T1DM subjects, since blood glucose levels are not immediately elevated due to its different metabolization.

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