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Abstract #0722

MR of hyperpolarized Xe-129 dissolved in the human brain at 1.5 T and 3.0 T

Madhwesha Rao1, Neil J Stewart1, Graham Norquay1, Paul D Griffiths1, and Jim M Wild1

1Academic unit of Radiology, University of Sheffield, Sheffield, United Kingdom

Xenon is an inert noble gas which can be safely inhaled. In the lungs, it diffuses into the bloodstream and is then transported to distal organs (brain, kidneys and liver). In this study, we have directly imaged the uptake of hyerpolarized 129Xe in the human brain in vivo. Thus demonstrated the feasibility as a safe and non-invasive contrast agent for functional imaging of the brain in diagnosing diseases related to cerebral perfusion such as brain ischemia. In addition, using tracer kinetic analysis we provide quantitative measurement for the intrinsic physiological characteristic of the blood brain barrier.

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