Abstract #0724

Quantitative Assessment of Pulmonary Blood Flow in Infants with Congenital Diaphragmatic Hernia by CINE Phase Contrast MRI

Jean A Tkach¹, Ryan A Moore², Nara S Higano^1,3,4, Laura L Walkup^1,3, Mantosh S Rattan⁵, Paul S Kingma⁶, Michael D Taylor², and Jason C Woods^1,3,4

¹Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ²The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ³Center for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ⁴Department of Physics, Washington University, St. Louis, MO, United States, ⁵Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ⁶Division of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States

Pulmonary arterial hypertension (PAH) is common in congenital diaphragmatic hernia (CDH) and is a major contributor to morbidity and mortality. Echocardiography and cardiac catheterization are the current standards for evaluating pulmonary hemodynamics in CDH infants, but both have significant limitations and/or risks. Phase contrast (PC) MRI can provide quantitative information about velocity and flow longitudinally, with minimal risk. We demonstrate the feasibility of applying PC MRI in the neonatal ICU (NICU) to obtain a quantitative assessment of pulmonary blood flow in CDH infants with the long-term goal to establish imaging biomarkers to predict PAH and assess therapeutic response.

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