Abstract #0725

Pretreatment intravoxel incoherent motion diffusion-weighted imaging for predicting the response of locally advanced rectal cancer to neoadjuvant chemoradiation therapy

Hongliang Sun¹, Yanyan Xu¹, Kaining Shi², and Wu Wang¹

¹Radiology, China-Japan Friendship hospital, Beijing, China, People's Republic of, ²Philips Healthcare China, Beijing, China, People's Republic of

Neoadjuvant chemoradiation therapy (CRT) followed by surgery has been established as the standard for locally advanced rectal cancer[1]. The treatment response after CRT is normally evaluated by MRI. However, MRI morphology techniques suffer from limitations in the interpretation of fibrotic scar tissue and inflammation. Diffusion weighted MRI has shown its potentially beneficial role for response evaluation, but with conflicting results[2]. Intravoxel incoherent motion (IVIM) which enable quantitative parameters that separately reflect tissue diffusivity and tissue microcapillary perfusion[3-4]. However, the pretreatment tumor IVIM MRI parameters predicting treatment response were not clarified.

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