Abstract #0738

Brain Reorganization in Young Children with Epilepsy Surgery: Longitudinal Tractography-Based Connectome Study

Jeong-Won Jeong^1,2, Eishi Asano¹, Csaba Juhasz^1,2, and Harry T. Chugani^1,2

¹Pediatrics and Neurology, Wayne State University, Detroit, MI, United States, ²Translational Imaging Laboratory, Children's Hospital of Michigan, Detroit, MI, United States

Both ictal and interictal epileptic activities can lead to progressive deterioration of affected brain structure and function with an additional indirect impairment of functional reorganization (or compensation) in no-epileptic areas. This study applies whole brain connectome analysis for children with intractable focal epilepsy in order to investigate the potential effect of epilepsy surgery and surgical outcome on the pattern of axonal plasticity in the contralateral hemisphere. We found that post-operative seizures are associated with increased connectivity, most pronounced in the temporal pole region of the contralateral hemisphere. Such increased connectivity may be an imaging marker of recurrent epilepsy after focal cortical resection.

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