Abstract #0739

Disrupted Development and Integrity of Frontal White Matter in Patients Treated for Pediatric Posterior Fossa Tumors

John O Glass¹, Robert J Ogg¹, Jung W Hyun², Julie H Harreld¹, Yimei Li², Amar Gajjar³, and Wilburn E Reddick¹

¹Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, United States, ²Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, United States, ³Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States

This study assessed the longitudinal white matter (WM) microstructure of 129 patients and 72 normal healthy age-similar controls. WM volume, fractional anisotropy (FA), and radial (RAD) and axial (AX) diffusivity trajectories were examined. After surgery but before any additional therapy, frontal WM volume in patients was similar to controls, while FA and AX were reduced in patients, suggestive of acute, indirect microstructural/axonal injury caused by disease and/or surgical excision. Over the next three years, AX, RAD, and WM volume decreased in patients, which would be consistent with possible resolution of axonal swelling combined with chronic demyelination.

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