Meeting Banner
Abstract #0750

The relationships between microstructure and the diffusion tensor in simulated skeletal muscle

David B Berry1, Benjamin M Regner2, Vitaly L Galinsky3, Samuel R Ward1,4,5, and Lawrence R Frank3

1Bioengineering, UCSD, La Jolla, CA, United States, 2Institute of Engineering in Medicine, UCSD, La Jolla, CA, United States, 3Center for Scientific Computation in Imaging, UCSD, La Jolla, CA, United States, 4Orthopaedic Surgery, UCSD, La Jolla, CA, United States, 5Radiology, UCSD, La Jolla, CA, United States

Diffusion tensor imaging (DTI) has been used to measure changes in restricted diffusion in skeletal muscle after injury, which are thought to track microstructural, and therefore functional changes. However, there are few direct comparisons between muscle microstructure and DTI measurements because it is difficult to precisely control in vivo experiments. Here, we use a computational (in silico) modeling approach to explore changes in DTI measurements as muscle microstructure is systemically changed. Muscle fiber diameter and edema have the largest effects on the DT. Additionally, we have shown multi-echo DTI is required to resolve changes in microstructure when edema is present.

This abstract and the presentation materials are available to members only; a login is required.

Join Here