Abstract #0750

The relationships between microstructure and the diffusion tensor in simulated skeletal muscle

David B Berry¹, Benjamin M Regner², Vitaly L Galinsky³, Samuel R Ward^1,4,5, and Lawrence R Frank³

¹Bioengineering, UCSD, La Jolla, CA, United States, ²Institute of Engineering in Medicine, UCSD, La Jolla, CA, United States, ³Center for Scientific Computation in Imaging, UCSD, La Jolla, CA, United States, ⁴Orthopaedic Surgery, UCSD, La Jolla, CA, United States, ⁵Radiology, UCSD, La Jolla, CA, United States

Diffusion tensor imaging (DTI) has been used to measure changes in restricted diffusion in skeletal muscle after injury, which are thought to track microstructural, and therefore functional changes. However, there are few direct comparisons between muscle microstructure and DTI measurements because it is difficult to precisely control in vivo experiments. Here, we use a computational (in silico) modeling approach to explore changes in DTI measurements as muscle microstructure is systemically changed. Muscle fiber diameter and edema have the largest effects on the DT. Additionally, we have shown multi-echo DTI is required to resolve changes in microstructure when edema is present.

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