Abstract #0754

Assessment of passive muscle elongation using DTI: Correlation between fiber length and diffusion coefficients

Valentina Mazzoli^1,2,3, Jos Oudeman¹, Marco A Marra³, Klaas Nicolay², Nico Verdonschot³, Andre M Sprengers³, Martijn Froeling⁴, Aart J Nederveen¹, and Gustav J Strijkers⁵

¹Department of Radiology, Academic Medical Center, Amsterdam, Netherlands, ²Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, ³Orthopaedic Research Lab, Radboud University Medical Center, Nijmegen, Netherlands, ⁴Department of Radiology, University Medical Center, Utrecht, Netherlands, ⁵Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands

The aim of this study is to explore Diffusion Tensor Imaging in the assessment of passive muscle elongation. We investigated two dorsiflexor and two plantarflexor muscles of the lower leg with the foot in dorsiflexion, neutral and plantarflexion position. Significant negative correlation was found between changes in fiberlength caused by passive muscle lengthening and radial diffusivity for all muscles. Furthermore the rate of change in radial diffusivity was compatible with a cylindrical model with constant volume. These findings give more insight into diffusion mechanisms in skeletal muscles and are highly relevant for biomechanical models.

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