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Abstract #0755

Age-Related Changes in Diffusion Tensor Imaging Measures in Human Skeletal Muscle

Donnie Cameron1, David A. Reiter1, Kenneth W. Fishbein1, Christopher M. Bergeron1, Richard G. Spencer1, and Luigi Ferrucci1

1National Institute on Aging, National Institutes of Health, Baltimore, MD, United States

This work investigates how ageing influences diffusion tensor imaging (DTI) measures through application of a robust protocol to the human thigh. Fifteen participants, from 27-73 years old, were recruited, and mean diffusivity (MD) and fractional anisotropy (FA) were calculated in their quadriceps and plotted against age. Fibre tractography was also calculated. Rectus femoris FA showed a significant correlation with age (R2=0.27, p=0.04), while FA approached significant correlations in other muscle heads. MD had a more complicated relationship with age, if any, in contrast to previous work where lipid influence was neglected. This highlights the need for high-quality fat-suppression in DTI.

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