Abstract #0755

Age-Related Changes in Diffusion Tensor Imaging Measures in Human Skeletal Muscle

Donnie Cameron¹, David A. Reiter¹, Kenneth W. Fishbein¹, Christopher M. Bergeron¹, Richard G. Spencer¹, and Luigi Ferrucci¹

¹National Institute on Aging, National Institutes of Health, Baltimore, MD, United States

This work investigates how ageing influences diffusion tensor imaging (DTI) measures through application of a robust protocol to the human thigh. Fifteen participants, from 27-73 years old, were recruited, and mean diffusivity (MD) and fractional anisotropy (FA) were calculated in their quadriceps and plotted against age. Fibre tractography was also calculated. Rectus femoris FA showed a significant correlation with age (R²=0.27, p=0.04), while FA approached significant correlations in other muscle heads. MD had a more complicated relationship with age, if any, in contrast to previous work where lipid influence was neglected. This highlights the need for high-quality fat-suppression in DTI.

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