Abstract #0756

A multimodal MR approach to evaluate complex muscle degeneration processes in Duchenne Muscular Dystrophy

Melissa Tamara Hooijmans¹, Melissa Tamara Hooijmans¹, Nathalie Doorenweerd¹, Jedrek Burakiewicz¹, Andrew Webb¹, Jan Vershuuren², Erik Niks², and Hermien Kan¹

¹Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Neurology, Leiden University Medical Center, Leiden, Netherlands

Quantitative MRI and MRS are increasingly important as non-invasive and objective outcome measures in therapy development for DMD. Several MR indices, have been shown to correlate individually with age and functional measures. However, much less attention has been given to how these indices relate to each other. Our work combined quantitative MRI and spatially resolved 31P MRS in the lower leg muscles of DMD patients and showed that combining multimodal MR measures is very important to objectively assess muscle degeneration processes and potentially the effect of therapeutic interventions in DMD.

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