Abstract #0757

Multi parametric MRI evaluation of skeletal muscle growth and myopathies in mice

Kerryanne V. Winters^1,2, Olivier Reynaud^1,2, Dmitry S. Novikov^1,2, Els Fieremans^1,2, and Sungheon G. Kim^1,2

¹Center of Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, NY, United States, ²Center for Advanced Imaging Innovation and Research, NYU Langone Medical Center, New York, NY, United States

The random permeable barrier membrane (RPBM) model for diffusion tensor imaging (DTI) provides a non-invasive modality potentially useful for early and accurate diagnosis for the wide range of myopathies. We have utilized the DTI-RPBM method to assess myofiber changes in the Surface-to-Volume ratio S/V and sarcolemma permeability κ as markers in growing and wasting skeletal muscle. Preliminary results show that S/V and κ decrease in both wild-type and mdx mice, with a more pronounced change between weeks 3 and 4 in mdx mice. The conventional IDEAL-Dixon and T2 mapping measures were not sensitive enough to observe the same change.

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