Kerryanne V. Winters1,2, Olivier Reynaud1,2, Dmitry S. Novikov1,2, Els Fieremans1,2, and Sungheon G. Kim1,2
1Center of Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, NY, United States, 2Center for Advanced Imaging Innovation and Research, NYU Langone Medical Center, New York, NY, United States
The random
permeable barrier membrane (RPBM) model for diffusion tensor imaging (DTI)
provides a non-invasive modality potentially useful for early and accurate
diagnosis for the wide range of myopathies. We have utilized the DTI-RPBM method
to assess myofiber changes in the Surface-to-Volume ratio S/V and sarcolemma permeability κ as markers in growing and wasting
skeletal muscle. Preliminary results show that S/V and κ decrease in
both wild-type and mdx mice, with a
more pronounced change between weeks 3 and 4 in mdx mice. The conventional
IDEAL-Dixon and T2 mapping measures were not sensitive enough to observe the
same change.
