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Abstract #0757

Multi parametric MRI evaluation of skeletal muscle growth and myopathies in mice

Kerryanne V. Winters1,2, Olivier Reynaud1,2, Dmitry S. Novikov1,2, Els Fieremans1,2, and Sungheon G. Kim1,2

1Center of Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, NY, United States, 2Center for Advanced Imaging Innovation and Research, NYU Langone Medical Center, New York, NY, United States

The random permeable barrier membrane (RPBM) model for diffusion tensor imaging (DTI) provides a non-invasive modality potentially useful for early and accurate diagnosis for the wide range of myopathies. We have utilized the DTI-RPBM method to assess myofiber changes in the Surface-to-Volume ratio S/V and sarcolemma permeability κ as markers in growing and wasting skeletal muscle. Preliminary results show that S/V and κ decrease in both wild-type and mdx mice, with a more pronounced change between weeks 3 and 4 in mdx mice. The conventional IDEAL-Dixon and T2 mapping measures were not sensitive enough to observe the same change.

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