Abstract #0759

Association of quadriceps muscle fat with isometric strength measurements in healthy males using chemical shift encoding-based water-fat MRI

Thomas Baum¹, Stephanie Inhuber², Michael Dieckmeyer¹, Christian Cordes¹, Stefan Ruschke¹, Elisabeth Klupp³, Holger Eggers⁴, Hendrik Kooijman⁵, Ernst J Rummeny¹, Ansgar Schwirtz², Jan S Kirschke³, and Dimitrios C Karampinos¹

¹Department of Radiology, TU Munich, Munich, Germany, ²Department of Sports and Health Sciences, TU Munich, Munich, Germany, ³Section of Neuroradiology, TU Munich, Munich, Germany, ⁴Philips Research Laboratory, Hamburg, Germany, ⁵Philips Healthcare, Hamburg, Germany

MR-based assessment of quadriceps muscle fat has been proposed as surrogate marker in sarcopenia, osteoarthritis, and neuromuscular disorders. The present study demonstrated strong associations between chemical shift encoding-based water-fat MRI quadriceps inter- and intramuscular fat parameters and corresponding physical strength measurements in healthy males. Thus, chemical shift encoding-based water-fat MRI can provide clinically important information beyond quadriceps muscle morphology and T1-weighted muscle fat quantifications and may potentially track early changes in muscles that are not severely atrophied or fatty infiltrated in the beginning of a disease process.

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