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Abstract #0759

Association of quadriceps muscle fat with isometric strength measurements in healthy males using chemical shift encoding-based water-fat MRI

Thomas Baum1, Stephanie Inhuber2, Michael Dieckmeyer1, Christian Cordes1, Stefan Ruschke1, Elisabeth Klupp3, Holger Eggers4, Hendrik Kooijman5, Ernst J Rummeny1, Ansgar Schwirtz2, Jan S Kirschke3, and Dimitrios C Karampinos1

1Department of Radiology, TU Munich, Munich, Germany, 2Department of Sports and Health Sciences, TU Munich, Munich, Germany, 3Section of Neuroradiology, TU Munich, Munich, Germany, 4Philips Research Laboratory, Hamburg, Germany, 5Philips Healthcare, Hamburg, Germany

MR-based assessment of quadriceps muscle fat has been proposed as surrogate marker in sarcopenia, osteoarthritis, and neuromuscular disorders. The present study demonstrated strong associations between chemical shift encoding-based water-fat MRI quadriceps inter- and intramuscular fat parameters and corresponding physical strength measurements in healthy males. Thus, chemical shift encoding-based water-fat MRI can provide clinically important information beyond quadriceps muscle morphology and T1-weighted muscle fat quantifications and may potentially track early changes in muscles that are not severely atrophied or fatty infiltrated in the beginning of a disease process.

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