Abstract #0764

Visual cortical responses to auditory stimulation during deep isoflurane anesthesia: an fMRI study

Celia M. Dong^1,2, Patrick P. Gao^1,2, Leon C. Ho^1,2, Alex T.L. Leong^1,2, Russell W. Chan^1,2, Xunda Wang^1,2, and Ed X. Wu^1,2

¹Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, People's Republic of, ²Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China, People's Republic of

Anesthesia is needed in many neuroscience studies but its effect on brain network response properties has not been fully understood. In particular, how it modulates crossmodal sensory responses remains largely unknown. This study investigated the brain responses to auditory stimulation at different isoflurane levels using large-view BOLD fMRI. Robust responses to multiple pure tone sound stimuli were detected in the bilateral visual cortex at 2.5% isoflurane but not at 1.0% isoflurane level. These results revealed the broad and profound modulation effects of anesthesia on brain crossmodal response properties during external sensory stimulation.

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