Abstract #0763

The acute effects of caffeine on brain oxygen metabolism: a dual calibrated FMRI study

Alberto Merola¹, Michael A Germuska¹, Esther AH Warnert¹, Sharmila Khot^1,2, Daniel Helme², Lewys Richmond², Kevin Murphy¹, and Richard G Wise¹

¹CUBRIC, Cardiff University, Cardiff, United Kingdom, ²Department of Anesthesia and Intensive Care Medicine, Cardiff University, Cardiff, United Kingdom

Caffeine acute effects on oxygen metabolism are not well characterized across the brain with MRI. We aim at measuring these in a double-blind, crossover, placebo-controlled study on sixteen healthy, moderate caffeine consumers using a dual calibrated fMRI approach and a novel forward estimation model. Results show spatial variations in OEF₀, CBF, CVR, venous CBV and CMRO₂ across grey matter at different levels of resolution (grey matter, ROI and voxel), in agreement with most of the literature findings. Therefore we propose this approach as the first viable method to assess the effects of drugs on brain metabolism with a voxel-wise resolution.

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