Abstract #0771

Structural Connectivity Changes in Refractory Childhood Absence Epilepsy

Graeme Jackson^1,2,3,4, Farnoosh Sadeghian¹, Patrick Carney¹, David Raffelt¹, Fernando Calamante^1,2, and Alan Connelly^1,2

¹The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, ²The Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia, ³Department of Medicine, The University of Melbourne, Melbourne, Australia, ⁴Department of Neurology, Austin Health, Melbourne, Australia

Childhood absence epilepsy (CAE) is a common neurological condition. Here we assessed white matter connectivity using fixel-based analysis (FBA) and grey matter structure using voxel-based morphometry in adult patients with refractory CAE. We identified increased grey matter volume in frontal lobe as well as decreased fibre connectivity in superior longitudinal fasciculi, right cingulum, motor area of corpus callosum and cerebellar peduncles. Our results reinforce the concept that the midline frontal areas are critically involved in the phenotype of generalised spike and wave discharges. These structural connectivity changes in CAE could be either developmental or as a consequence of seizures.

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