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Abstract #0776

MRI monitoring of epileptogenesis with direct histological validation

Niels Leonard Schwaderlapp1, Philipp Janz2, Ute Häussler2, Jan Korvink3, Dominik Elverfeldt1, Jürgen Hennig1, Carola Haas2, and Pierre LeVan1

1Medical Physics, University Medical Center Freiburg, Freiburg, Germany, 2Experimental Epilepsy Research, University Medical Center Freiburg, Freiburg, Germany, 3Institut für Mikrostrukturtechnik, Karlsruher Institut für Technologie, Karlsruhe, Germany

Cellular-level pathological changes in the kainate mouse model of temporal lobe epilepsy (TLE) have been well-characterized immunohistochemically (IHC) and include neuronal injury followed by granule cell dispersion. In this work, we demonstrate the possibility to non-invasively track granule cell dispersion and neuronal injury using diffusion imaging and 1H-spectroscopy. The volume of the dispersed granule cell layer quantified by DTI and the initial injury reflected by a reduction of NAA and glutamate are quantitatively validated with IHC and can be used as early markers of epileptogenicity in this mouse model of TLE.

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