Abstract #0776

MRI monitoring of epileptogenesis with direct histological validation

Niels Leonard Schwaderlapp¹, Philipp Janz², Ute Häussler², Jan Korvink³, Dominik Elverfeldt¹, Jürgen Hennig¹, Carola Haas², and Pierre LeVan¹

¹Medical Physics, University Medical Center Freiburg, Freiburg, Germany, ²Experimental Epilepsy Research, University Medical Center Freiburg, Freiburg, Germany, ³Institut für Mikrostrukturtechnik, Karlsruher Institut für Technologie, Karlsruhe, Germany

Cellular-level pathological changes in the kainate mouse model of temporal lobe epilepsy (TLE) have been well-characterized immunohistochemically (IHC) and include neuronal injury followed by granule cell dispersion. In this work, we demonstrate the possibility to non-invasively track granule cell dispersion and neuronal injury using diffusion imaging and ¹H-spectroscopy. The volume of the dispersed granule cell layer quantified by DTI and the initial injury reflected by a reduction of NAA and glutamate are quantitatively validated with IHC and can be used as early markers of epileptogenicity in this mouse model of TLE.

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