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Abstract #0778

Automated fibre quantification of the fornix predicts outcome after surgery for intractable temporal lobe epilepsy

Russell Glenn1, Leonardo Bonilha1, Barbara Kreilkamp2, Mark P Richardson3, Bernd Weber4, and Simon S Keller2

1Medical University of South Carolina, Charleston, SC, United States, 2University of Liverpool, Liverpool, United Kingdom, 3King's College London, London, United Kingdom, 4University Hospital Bonn, Bonn, Germany

Imaging markers of postoperative seizure control in refractory temporal lobe epilepsy (TLE) would provide a useful clinical tool for surgical decision making. In the present diffusion tensor imaging study, we report that regional tissue characteristics of the fornix ipsilateral to the side of intended resection are related to postoperative seizure control in patients with TLE. Interestingly, areas found to be abnormal only in patients with a suboptimal outcome were located outside the margins of resection. The identification of fornical abnormalities outside the area of intended resection may be an important prognostic marker of suboptimal seizure control after temporal lobe surgery.

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