Abstract #0779

Individual measures of network efficiency in patients with epilepsy based on cortical thickness

Gerhard Drenthen^1,2, Marielle Vlooswijk^2,3, Marian Majoie², Paul Hofman^1,2, Albert Aldenkamp^2,3, Walter Backes^1,2, and Jacobus Jansen^1,2

¹Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ²School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands, ³Department of Neurology, Maastricht University Medical Center, Maastricht, Netherlands

Brain network analysis that infers on interregional correlations of anatomical features usually makes use of intersubject correlation matrices that characterize variations over subjects. Here, a novel method is introduced that provides measures of network efficiency on an individual basis in patients with epilepsy. To this end, for each participant a measure of deviation from a group of healthy controls is calculated, and compared to the small-world parameters (clustering coefficient and minimum path length) of a reference graph obtained for the native control group. Results show that patients with epilepsy exhibit a less efficient network compared to controls.

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