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Abstract #0793

Challenges in solving the two-compartment free-water diffusion MRI model

Ørjan Bergmann1,2, Carl-Fredrik Westin1, and Ofer Pasternak1

1Dept of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 2Norwegian Competency Center for MS, Haukeland University Hospital, Bergen, Norway

In this work we explore the solution space of the two-compartment free-water problem under different noise levels. Based on the shape of the solution space we show that solving this model in an intuitive and straightforward manner may result in solutions which are sensitive to noise, and that are biased towards neglecting the free-water component. Although multi-shell techniques improve the situation we show that more advanced methods are required to further stabilize the solution.

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