Abstract #0794

Quantification of demyelination and remyelination with diffusion MRI: specific in vivo White Matter Tract Integrity metrics agree with electron microscopy-derived features

Ileana O Jelescu¹, Magdalena Zurek¹, Kerryanne V Winters¹, Jelle Veraart¹, Anjali Rajaratnam¹, Nathanael S Kim¹, James S Babb¹, Timothy M Shepherd¹, Dmitry S Novikov¹, Sungheon G Kim¹, and Els Fieremans¹

¹Center for Biomedical Imaging, Radiology, New York University School of Medicine, New York, NY, United States

White Matter Tract Integrity (WMTI) metrics derived from diffusion data provide a compartment-specific characterization of white matter. Here, we evaluated the specificity of the axonal water fraction (AWF) and extra-axonal radial diffusivity (D_e,┴) by assessing their correlations to metrics derived from electron microscopy (EM), in the splenium of control, cuprizone-treated and recovering mice. As the model predicted, the WMTI-derived AWF correlated very strongly with the EM-derived AWF, but not with the g-ratio, while D_e,┴ correlated with the g-ratio, but not with the EM-derived AWF. WMTI parameters are therefore promising biomarkers for specific biophysical aspects of white matter pathology in vivo.

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