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Abstract #0794

Quantification of demyelination and remyelination with diffusion MRI: specific in vivo White Matter Tract Integrity metrics agree with electron microscopy-derived features

Ileana O Jelescu1, Magdalena Zurek1, Kerryanne V Winters1, Jelle Veraart1, Anjali Rajaratnam1, Nathanael S Kim1, James S Babb1, Timothy M Shepherd1, Dmitry S Novikov1, Sungheon G Kim1, and Els Fieremans1

1Center for Biomedical Imaging, Radiology, New York University School of Medicine, New York, NY, United States

White Matter Tract Integrity (WMTI) metrics derived from diffusion data provide a compartment-specific characterization of white matter. Here, we evaluated the specificity of the axonal water fraction (AWF) and extra-axonal radial diffusivity (De,┴) by assessing their correlations to metrics derived from electron microscopy (EM), in the splenium of control, cuprizone-treated and recovering mice. As the model predicted, the WMTI-derived AWF correlated very strongly with the EM-derived AWF, but not with the g-ratio, while De,┴ correlated with the g-ratio, but not with the EM-derived AWF. WMTI parameters are therefore promising biomarkers for specific biophysical aspects of white matter pathology in vivo.

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