Abstract #0795

Exploring fibre orientation dispersion in the corpus callosum: Comparison of Diffusion MRI, Polarized Light Imaging and Histology

Jeroen Mollink^1,2, Michiel Kleinnijenhuis¹, Stamatios N Sotiropoulos¹, Michiel Cottaar¹, Anne-Marie van Cappellen van Walsum², Menuka Pallebage Gamarallage³, Olaf Ansorge³, Saad Jbabdi¹, and Karla L Miller¹

¹FMRIB centre, University of Oxford, Oxford, United Kingdom, ²Donders Institute for Brain, Cognition and Behaviour, Department of Anatomy, Radboud University Medical Centre, Nijmegen, Netherlands, ³Department of Neuropathology, University of Oxford, Oxford, United Kingdom

In this study we explored fibre orientation dispersion in the corpus callosum using diffusion-weighted MRI, Polarized Light Imaging and Histology. Microscopic fibre orientations were derived from Polarized Light Imaging and histological myelin and glial cell staining, with the aim of understanding the microstructural features that correlate with the diffusion signal.

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