Abstract #0799

Characterization of Myocardial Fiber Orientation to Assess Therapeutic Exosomes from Cardiosphere-derived Cells (CDCs) in Myocardial Infarcted Porcine with In Vivo Diffusion-Tensor CMR on a Clinical Scanner

Christopher Nguyen¹, James Dawkins², Xiaoming Bi³, Debiao Li^1,4, and Eduardo Marban²

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ³Siemens Healthcare, Los Angeles, CA, United States, ⁴Bioengineering, University of California Los Angeles, Los Angeles, CA, United States

Diffusion-Tensor cardiovascular magnetic resonance (DT-CMR) is capable of mapping myocardial fiber orientation. In myocardial infarction (MI) murine models, DT-CMR can identify the effects of stem cell therapy on myocardial fiber orientations. The study illustrated the powerful potential of DT-CMR in identifying adverse treatment despite successful delivery of viable stem cells. However, it remains to be seen if this recent work is translatable to large animal and clinical studies. In a MI porcine model, in vivo DT-CMR revealed that myocardial fiber orientation was preserved with CDC-derived exosome treatment and adversely changed with placebo treatment consistent with observed viability and function changes.

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