Meeting Banner
Abstract #0799

Characterization of Myocardial Fiber Orientation to Assess Therapeutic Exosomes from Cardiosphere-derived Cells (CDCs) in Myocardial Infarcted Porcine with In Vivo Diffusion-Tensor CMR on a Clinical Scanner

Christopher Nguyen1, James Dawkins2, Xiaoming Bi3, Debiao Li1,4, and Eduardo Marban2

1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 3Siemens Healthcare, Los Angeles, CA, United States, 4Bioengineering, University of California Los Angeles, Los Angeles, CA, United States

Diffusion-Tensor cardiovascular magnetic resonance (DT-CMR) is capable of mapping myocardial fiber orientation. In myocardial infarction (MI) murine models, DT-CMR can identify the effects of stem cell therapy on myocardial fiber orientations. The study illustrated the powerful potential of DT-CMR in identifying adverse treatment despite successful delivery of viable stem cells. However, it remains to be seen if this recent work is translatable to large animal and clinical studies. In a MI porcine model, in vivo DT-CMR revealed that myocardial fiber orientation was preserved with CDC-derived exosome treatment and adversely changed with placebo treatment consistent with observed viability and function changes.

This abstract and the presentation materials are available to members only; a login is required.

Join Here