Abstract #0800

Resolving Microscopic Fractional Anisotropy in the Heart

Irvin Teh¹, Henrik Lundell², Hannah J Whittington¹, Tim Bjørn Dyrby², and Jürgen E Schneider¹

¹Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, ²Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark

Diffusion tensor imaging (DTI) is widely used for structural characterization of the heart. However, the measured fractional anisotropy (FA) is influenced by diffusion anisotropy as well as orientation dispersion. In the heart, orientation dispersion is ubiquitous and stems from the transmural variation in cardiomyocyte orientation and regions where multiple cell populations intersect. We propose microscopic FA (µFA) as a more robust measure of intrinsic diffusion anisotropy that is insensitive to orientation dispersion, and demonstrate this with simulations and ex vivo MRI.

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